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Systemic Sclerosis Classification Criteria: Developing methods for multi-criteria decision analysis with 1000Minds

Identifieur interne : 001046 ( Main/Exploration ); précédent : 001045; suivant : 001047

Systemic Sclerosis Classification Criteria: Developing methods for multi-criteria decision analysis with 1000Minds

Auteurs : Sindhu R. Johnson [Canada] ; Raymond P. Naden [Nouvelle-Zélande] ; Jaap Fransen [Pays-Bas] ; Frank Van Den Hoogen [Pays-Bas] ; Janet E. Pope [Canada] ; Murray Baron [Canada] ; Alan Tyndall [Suisse] ; Marco Matucci-Cerinic [Italie] ; Christopher P. Denton [Royaume-Uni] ; Oliver Distler [Suisse] ; Armando Gabrielli [Italie] ; Jacob M. Van Laar [Royaume-Uni] ; Maureen Mayes [États-Unis] ; Virginia Steen [États-Unis] ; James R. Seibold [États-Unis] ; Phillip Clements [États-Unis] ; Thomas A. Medsger [États-Unis] ; Patricia E. Carreira [Espagne] ; Gabriela Riemekasten [Allemagne] ; Lorinda Chung [États-Unis] ; Barri J. Fessler ; Peter A. Merkel [États-Unis] ; Richard Silver [États-Unis] ; John Varga [États-Unis] ; Yannick Allanore ; Ulf Mueller-Ladner [Allemagne] ; Madelon C. Vonk [Pays-Bas] ; Ulrich A. Walker [Suisse] ; Susanna Cappelli [Italie] ; Dinesh Khanna [États-Unis]

Source :

Journal of clinical epidemiology [ 0895-4356 ] ; 2014.

RBID : PMC:4134523

Descripteurs français

KwdFr :
- Consensus, Humains, Recherche biomédicale (instrumentation), Reproductibilité des résultats, Sclérodermie systémique (), Sclérodermie systémique (diagnostic), Techniques d'aide à la décision, Études de faisabilité.
MESH :
- diagnostic : Sclérodermie systémique.
- Consensus, Humains, Recherche biomédicale, Reproductibilité des résultats, Sclérodermie systémique, Techniques d'aide à la décision, Études de faisabilité.

English descriptors

KwdEn :
- Biomedical Research (instrumentation), Consensus, Decision Support Techniques, Feasibility Studies, Humans, Reproducibility of Results, Scleroderma, Systemic (classification), Scleroderma, Systemic (diagnosis).
MESH :
- classification : Scleroderma, Systemic.
- diagnosis : Scleroderma, Systemic.
- instrumentation : Biomedical Research.
- Consensus, Decision Support Techniques, Feasibility Studies, Humans, Reproducibility of Results.

Abstract

Objective

Classification criteria for systemic sclerosis (SSc) are being developed. The objectives were to: develop an instrument for collating case-data and evaluate its sensibility; use forced-choice methods to reduce and weight criteria; and explore agreement between experts on the probability that cases were classified as SSc.

Study Design and Setting

A standardized instrument was tested for sensibility. The instrument was applied to 20 cases covering a range of probabilities that each had SSc. Experts rank-ordered cases from highest to lowest probability; reduced and weighted the criteria using forced-choice methods; and re-ranked the cases. Consistency in rankings was evaluated using intraclass correlation coefficients (ICC).

Results

Experts endorsed clarity (83%), comprehensibility (100%), face and content validity (100%). Criteria were weighted (points): finger skin thickening (14–22), finger-tip lesions (9–21), friction rubs (21), finger flexion contractures (16), pulmonary fibrosis (14), SSc-related antibodies (15), Raynaud’s phenomenon (13), calcinosis (12), pulmonary hypertension (11), renal crisis (11), telangiectasia (10), abnormal nailfold capillaries (10), esophageal dilation (7) and puffy fingers (5). The ICC across experts was 0.73 (95%CI 0.58,0.86) and improved to 0.80 (95%CI 0.68,0.90).

Conclusions

Using a sensible instrument and forced-choice methods, the number of criteria were reduced by 39% (23 to 14) and weighted. Our methods reflect the rigors of measurement science, and serves as a template for developing classification criteria.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4134523

DOI: 10.1016/j.jclinepi.2013.12.009
PubMed: 24721558
PubMed Central: 4134523

Affiliations:

Allemagne, Canada, Espagne, Italie, Nouvelle-Zélande, Pays-Bas, Royaume-Uni, Suisse, États-Unis
Angleterre, Berlin, Californie, Communauté de Madrid, Connecticut, Grand Londres, Gueldre, Illinois, Michigan, Ontario, Pennsylvanie, Québec, Texas
Berlin, Londres, Madrid, Montréal, Nimègue, Toronto
Université McGill, Université de Toronto

Le document en format XML

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<author><name sortKey="Merkel, Peter A" sort="Merkel, Peter A" uniqKey="Merkel P" first="Peter A." last="Merkel">Peter A. Merkel</name>
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<author><name sortKey="Cappelli, Susanna" sort="Cappelli, Susanna" uniqKey="Cappelli S" first="Susanna" last="Cappelli">Susanna Cappelli</name>
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<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Rheumatology AVC, Department of BioMedicine, Division of Rheumatology AOUC, Department of Medicine & Denothecentre, University of Florence, Firenze</wicri:regionArea>
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<author><name sortKey="Khanna, Dinesh" sort="Khanna, Dinesh" uniqKey="Khanna D" first="Dinesh" last="Khanna">Dinesh Khanna</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Rheumatology, University of Michigan Scleroderma Program, Ann Arbor, MI</wicri:regionArea>
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<region type="state">Ontario</region>
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</affiliation>
</author>
<author><name sortKey="Naden, Raymond P" sort="Naden, Raymond P" uniqKey="Naden R" first="Raymond P." last="Naden">Raymond P. Naden</name>
<affiliation wicri:level="1"><nlm:aff id="A2">Auckland City Hospital, Auckland, New Zealand</nlm:aff>
<country xml:lang="fr">Nouvelle-Zélande</country>
<wicri:regionArea>Auckland City Hospital, Auckland</wicri:regionArea>
<wicri:noRegion>Auckland</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Fransen, Jaap" sort="Fransen, Jaap" uniqKey="Fransen J" first="Jaap" last="Fransen">Jaap Fransen</name>
<affiliation wicri:level="3"><nlm:aff id="A3">Department of Rheumatic Diseases, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Rheumatic Diseases, Radboud University Nijmegen Medical Centre, Nijmegen</wicri:regionArea>
<placeName><settlement type="city">Nimègue</settlement>
<region type="province" nuts="2">Gueldre</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Van Den Hoogen, Frank" sort="Van Den Hoogen, Frank" uniqKey="Van Den Hoogen F" first="Frank" last="Van Den Hoogen">Frank Van Den Hoogen</name>
<affiliation wicri:level="3"><nlm:aff id="A4">Rheumatology Centre, Sint Maartenskliniek, Nijmegen, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Rheumatology Centre, Sint Maartenskliniek, Nijmegen</wicri:regionArea>
<placeName><settlement type="city">Nimègue</settlement>
<region type="province" nuts="2">Gueldre</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pope, Janet E" sort="Pope, Janet E" uniqKey="Pope J" first="Janet E." last="Pope">Janet E. Pope</name>
<affiliation wicri:level="1"><nlm:aff id="A5">Division of Rheumatology, Department of Medicine, St Joseph Health Care, University of Western Ontario, London, ON, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Division of Rheumatology, Department of Medicine, St Joseph Health Care, University of Western Ontario, London, ON</wicri:regionArea>
<wicri:noRegion>ON</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Baron, Murray" sort="Baron, Murray" uniqKey="Baron M" first="Murray" last="Baron">Murray Baron</name>
<affiliation wicri:level="4"><nlm:aff id="A6">Division of Rheumatology, Department of Medicine, Jewish General Hospital, McGill University, Montreal, QC, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Division of Rheumatology, Department of Medicine, Jewish General Hospital, McGill University, Montreal, QC</wicri:regionArea>
<orgName type="university">Université McGill</orgName>
<placeName><settlement type="city">Montréal</settlement>
<region type="state">Québec</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tyndall, Alan" sort="Tyndall, Alan" uniqKey="Tyndall A" first="Alan" last="Tyndall">Alan Tyndall</name>
<affiliation wicri:level="1"><nlm:aff id="A7">Rheumatology Department, University of Basel, Basel, Switzerland</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Rheumatology Department, University of Basel, Basel</wicri:regionArea>
<wicri:noRegion>Basel</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Matucci Cerinic, Marco" sort="Matucci Cerinic, Marco" uniqKey="Matucci Cerinic M" first="Marco" last="Matucci-Cerinic">Marco Matucci-Cerinic</name>
<affiliation wicri:level="1"><nlm:aff id="A8">Department of Rheumatology AVC, Department of BioMedicine, Division of Rheumatology AOUC, Department of Medicine & Denothecentre, University of Florence, Firenze, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Rheumatology AVC, Department of BioMedicine, Division of Rheumatology AOUC, Department of Medicine & Denothecentre, University of Florence, Firenze</wicri:regionArea>
<wicri:noRegion>Firenze</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Denton, Christopher P" sort="Denton, Christopher P" uniqKey="Denton C" first="Christopher P." last="Denton">Christopher P. Denton</name>
<affiliation wicri:level="3"><nlm:aff id="A9">Centre for Rheumatology and Connective Tissue Diseases, Royal Free Hospital, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Rheumatology and Connective Tissue Diseases, Royal Free Hospital, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Distler, Oliver" sort="Distler, Oliver" uniqKey="Distler O" first="Oliver" last="Distler">Oliver Distler</name>
<affiliation wicri:level="1"><nlm:aff id="A10">Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Department of Rheumatology, University Hospital Zurich, Zurich</wicri:regionArea>
<wicri:noRegion>Zurich</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gabrielli, Armando" sort="Gabrielli, Armando" uniqKey="Gabrielli A" first="Armando" last="Gabrielli">Armando Gabrielli</name>
<affiliation wicri:level="1"><nlm:aff id="A11">Dipartimento di Scienze Cliniche e Molecolari, Clinica Medica, Università Politecnica delle Marche, Ancona, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Dipartimento di Scienze Cliniche e Molecolari, Clinica Medica, Università Politecnica delle Marche, Ancona</wicri:regionArea>
<wicri:noRegion>Ancona</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Van Laar, Jacob M" sort="Van Laar, Jacob M" uniqKey="Van Laar J" first="Jacob M." last="Van Laar">Jacob M. Van Laar</name>
<affiliation wicri:level="1"><nlm:aff id="A12">Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne</wicri:regionArea>
<wicri:noRegion>Newcastle upon Tyne</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mayes, Maureen" sort="Mayes, Maureen" uniqKey="Mayes M" first="Maureen" last="Mayes">Maureen Mayes</name>
<affiliation wicri:level="2"><nlm:aff id="A13">The University of Texas Health Science Center-Houston, Houston, TX, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The University of Texas Health Science Center-Houston, Houston, TX</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Steen, Virginia" sort="Steen, Virginia" uniqKey="Steen V" first="Virginia" last="Steen">Virginia Steen</name>
<affiliation wicri:level="1"><nlm:aff id="A14">Department of Medicine, Division of Rheumatology, Clinical Immunology and Allergy, Georgetown University School of Medicine, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, Division of Rheumatology, Clinical Immunology and Allergy, Georgetown University School of Medicine</wicri:regionArea>
<wicri:noRegion>Georgetown University School of Medicine</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Seibold, James R" sort="Seibold, James R" uniqKey="Seibold J" first="James R." last="Seibold">James R. Seibold</name>
<affiliation wicri:level="2"><nlm:aff id="A15">Scleroderma Research Consultants, Avon, Connecticut, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Scleroderma Research Consultants, Avon, Connecticut</wicri:regionArea>
<placeName><region type="state">Connecticut</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Clements, Phillip" sort="Clements, Phillip" uniqKey="Clements P" first="Phillip" last="Clements">Phillip Clements</name>
<affiliation wicri:level="1"><nlm:aff id="A16">Department of Medicine, David Geffen School of Medicine at UCLA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, David Geffen School of Medicine at UCLA</wicri:regionArea>
<wicri:noRegion>David Geffen School of Medicine at UCLA</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Medsger, Thomas A" sort="Medsger, Thomas A" uniqKey="Medsger T" first="Thomas A." last="Medsger">Thomas A. Medsger</name>
<affiliation wicri:level="2"><nlm:aff id="A17">Department of Medicine, Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Carreira, Patricia E" sort="Carreira, Patricia E" uniqKey="Carreira P" first="Patricia E." last="Carreira">Patricia E. Carreira</name>
<affiliation wicri:level="3"><nlm:aff id="A18">Servicio de Reumatología, Hospital Universitario 12 de Octubre, Madrid, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Servicio de Reumatología, Hospital Universitario 12 de Octubre, Madrid</wicri:regionArea>
<placeName><settlement type="city">Madrid</settlement>
<region nuts="2" type="region">Communauté de Madrid</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Riemekasten, Gabriela" sort="Riemekasten, Gabriela" uniqKey="Riemekasten G" first="Gabriela" last="Riemekasten">Gabriela Riemekasten</name>
<affiliation wicri:level="3"><nlm:aff id="A19">Department of Rheumatology, German Rheumatology Research Center, Leibniz Institute, Berlin, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Rheumatology, German Rheumatology Research Center, Leibniz Institute, Berlin</wicri:regionArea>
<placeName><region type="land" nuts="3">Berlin</region>
<settlement type="city">Berlin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chung, Lorinda" sort="Chung, Lorinda" uniqKey="Chung L" first="Lorinda" last="Chung">Lorinda Chung</name>
<affiliation wicri:level="2"><nlm:aff id="A20">Department of Medicine and Dermatology, Division of Immunology and Rheumatology, Stanford University, Stanford, CA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine and Dermatology, Division of Immunology and Rheumatology, Stanford University, Stanford, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fessler, Barri J" sort="Fessler, Barri J" uniqKey="Fessler B" first="Barri J." last="Fessler">Barri J. Fessler</name>
<affiliation><nlm:aff id="A21">Division of Clinical Immunology and Rheumatology, The University of Alabama at Birmingham</nlm:aff>
<wicri:noCountry code="subfield">The University of Alabama at Birmingham</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Merkel, Peter A" sort="Merkel, Peter A" uniqKey="Merkel P" first="Peter A." last="Merkel">Peter A. Merkel</name>
<affiliation wicri:level="2"><nlm:aff id="A22">Division of Rheumatology, The University of Pennsylvania, Philadelphia, PA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Rheumatology, The University of Pennsylvania, Philadelphia, PA</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Silver, Richard" sort="Silver, Richard" uniqKey="Silver R" first="Richard" last="Silver">Richard Silver</name>
<affiliation wicri:level="1"><nlm:aff id="A23">Department of Medicine, Division of Rheumatology & Immunology, Medical University of South Carolina, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, Division of Rheumatology & Immunology, Medical University of South Carolina</wicri:regionArea>
<wicri:noRegion>Medical University of South Carolina</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Varga, John" sort="Varga, John" uniqKey="Varga J" first="John" last="Varga">John Varga</name>
<affiliation wicri:level="2"><nlm:aff id="A24">Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Illinois</region>
</placeName>
<wicri:cityArea>Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Allanore, Yannick" sort="Allanore, Yannick" uniqKey="Allanore Y" first="Yannick" last="Allanore">Yannick Allanore</name>
<affiliation><nlm:aff id="A25">Rheumatology A Department, Paris Descartes University, Cochin Hospital</nlm:aff>
<wicri:noCountry code="subfield">Cochin Hospital</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Mueller Ladner, Ulf" sort="Mueller Ladner, Ulf" uniqKey="Mueller Ladner U" first="Ulf" last="Mueller-Ladner">Ulf Mueller-Ladner</name>
<affiliation wicri:level="1"><nlm:aff id="A26">Department of Rheumatology and Clinical Immunology, Justus-Liebig University Giessen, Kerckhoff Clinic, Bad Nauheim, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Rheumatology and Clinical Immunology, Justus-Liebig University Giessen, Kerckhoff Clinic, Bad Nauheim</wicri:regionArea>
<wicri:noRegion>Bad Nauheim</wicri:noRegion>
<wicri:noRegion>Bad Nauheim</wicri:noRegion>
<wicri:noRegion>Bad Nauheim</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Vonk, Madelon C" sort="Vonk, Madelon C" uniqKey="Vonk M" first="Madelon C." last="Vonk">Madelon C. Vonk</name>
<affiliation wicri:level="3"><nlm:aff id="A3">Department of Rheumatic Diseases, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Rheumatic Diseases, Radboud University Nijmegen Medical Centre, Nijmegen</wicri:regionArea>
<placeName><settlement type="city">Nimègue</settlement>
<region type="province" nuts="2">Gueldre</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Walker, Ulrich A" sort="Walker, Ulrich A" uniqKey="Walker U" first="Ulrich A." last="Walker">Ulrich A. Walker</name>
<affiliation wicri:level="1"><nlm:aff id="A7">Rheumatology Department, University of Basel, Basel, Switzerland</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Rheumatology Department, University of Basel, Basel</wicri:regionArea>
<wicri:noRegion>Basel</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Cappelli, Susanna" sort="Cappelli, Susanna" uniqKey="Cappelli S" first="Susanna" last="Cappelli">Susanna Cappelli</name>
<affiliation wicri:level="1"><nlm:aff id="A8">Department of Rheumatology AVC, Department of BioMedicine, Division of Rheumatology AOUC, Department of Medicine & Denothecentre, University of Florence, Firenze, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Rheumatology AVC, Department of BioMedicine, Division of Rheumatology AOUC, Department of Medicine & Denothecentre, University of Florence, Firenze</wicri:regionArea>
<wicri:noRegion>Firenze</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Khanna, Dinesh" sort="Khanna, Dinesh" uniqKey="Khanna D" first="Dinesh" last="Khanna">Dinesh Khanna</name>
<affiliation wicri:level="2"><nlm:aff id="A27">Division of Rheumatology, University of Michigan Scleroderma Program, Ann Arbor, MI, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Rheumatology, University of Michigan Scleroderma Program, Ann Arbor, MI</wicri:regionArea>
<placeName><region type="state">Michigan</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Journal of clinical epidemiology</title>
<idno type="ISSN">0895-4356</idno>
<idno type="eISSN">1878-5921</idno>
<imprint><date when="2014">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Biomedical Research (instrumentation)</term>
<term>Consensus</term>
<term>Decision Support Techniques</term>
<term>Feasibility Studies</term>
<term>Humans</term>
<term>Reproducibility of Results</term>
<term>Scleroderma, Systemic (classification)</term>
<term>Scleroderma, Systemic (diagnosis)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Consensus</term>
<term>Humains</term>
<term>Recherche biomédicale (instrumentation)</term>
<term>Reproductibilité des résultats</term>
<term>Sclérodermie systémique ()</term>
<term>Sclérodermie systémique (diagnostic)</term>
<term>Techniques d'aide à la décision</term>
<term>Études de faisabilité</term>
</keywords>
<keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Scleroderma, Systemic</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Scleroderma, Systemic</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Sclérodermie systémique</term>
</keywords>
<keywords scheme="MESH" qualifier="instrumentation" xml:lang="en"><term>Biomedical Research</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Consensus</term>
<term>Decision Support Techniques</term>
<term>Feasibility Studies</term>
<term>Humans</term>
<term>Reproducibility of Results</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Consensus</term>
<term>Humains</term>
<term>Recherche biomédicale</term>
<term>Reproductibilité des résultats</term>
<term>Sclérodermie systémique</term>
<term>Techniques d'aide à la décision</term>
<term>Études de faisabilité</term>
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<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Objective</title>
<p id="P1">Classification criteria for systemic sclerosis (SSc) are being developed. The objectives were to: develop an instrument for collating case-data and evaluate its sensibility; use forced-choice methods to reduce and weight criteria; and explore agreement between experts on the probability that cases were classified as SSc.</p>
</sec>
<sec id="S2"><title>Study Design and Setting</title>
<p id="P2">A standardized instrument was tested for sensibility. The instrument was applied to 20 cases covering a range of probabilities that each had SSc. Experts rank-ordered cases from highest to lowest probability; reduced and weighted the criteria using forced-choice methods; and re-ranked the cases. Consistency in rankings was evaluated using intraclass correlation coefficients (ICC).</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">Experts endorsed clarity (83%), comprehensibility (100%), face and content validity (100%). Criteria were weighted (points): finger skin thickening (<xref rid="R14" ref-type="bibr">14</xref>
–<xref rid="R22" ref-type="bibr">22</xref>
), finger-tip lesions (<xref rid="R9" ref-type="bibr">9</xref>
–<xref rid="R21" ref-type="bibr">21</xref>
), friction rubs (<xref rid="R21" ref-type="bibr">21</xref>
), finger flexion contractures (<xref rid="R16" ref-type="bibr">16</xref>
), pulmonary fibrosis (<xref rid="R14" ref-type="bibr">14</xref>
), SSc-related antibodies (<xref rid="R15" ref-type="bibr">15</xref>
), Raynaud’s phenomenon (<xref rid="R13" ref-type="bibr">13</xref>
), calcinosis (<xref rid="R12" ref-type="bibr">12</xref>
), pulmonary hypertension (<xref rid="R11" ref-type="bibr">11</xref>
), renal crisis (<xref rid="R11" ref-type="bibr">11</xref>
), telangiectasia (<xref rid="R10" ref-type="bibr">10</xref>
), abnormal nailfold capillaries (<xref rid="R10" ref-type="bibr">10</xref>
), esophageal dilation (<xref rid="R7" ref-type="bibr">7</xref>
) and puffy fingers (<xref rid="R5" ref-type="bibr">5</xref>
). The ICC across experts was 0.73 (95%CI 0.58,0.86) and improved to 0.80 (95%CI 0.68,0.90).</p>
</sec>
<sec id="S4"><title>Conclusions</title>
<p id="P4">Using a sensible instrument and forced-choice methods, the number of criteria were reduced by 39% (23 to 14) and weighted. Our methods reflect the rigors of measurement science, and serves as a template for developing classification criteria.</p>
</sec>
</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>Canada</li>
<li>Espagne</li>
<li>Italie</li>
<li>Nouvelle-Zélande</li>
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<li>Royaume-Uni</li>
<li>Suisse</li>
<li>États-Unis</li>
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<li>Berlin</li>
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</settlement>
<orgName><li>Université McGill</li>
<li>Université de Toronto</li>
</orgName>
</list>
<tree><noCountry><name sortKey="Allanore, Yannick" sort="Allanore, Yannick" uniqKey="Allanore Y" first="Yannick" last="Allanore">Yannick Allanore</name>
<name sortKey="Fessler, Barri J" sort="Fessler, Barri J" uniqKey="Fessler B" first="Barri J." last="Fessler">Barri J. Fessler</name>
</noCountry>
<country name="Canada"><region name="Ontario"><name sortKey="Johnson, Sindhu R" sort="Johnson, Sindhu R" uniqKey="Johnson S" first="Sindhu R." last="Johnson">Sindhu R. Johnson</name>
</region>
<name sortKey="Baron, Murray" sort="Baron, Murray" uniqKey="Baron M" first="Murray" last="Baron">Murray Baron</name>
<name sortKey="Pope, Janet E" sort="Pope, Janet E" uniqKey="Pope J" first="Janet E." last="Pope">Janet E. Pope</name>
</country>
<country name="Nouvelle-Zélande"><noRegion><name sortKey="Naden, Raymond P" sort="Naden, Raymond P" uniqKey="Naden R" first="Raymond P." last="Naden">Raymond P. Naden</name>
</noRegion>
</country>
<country name="Pays-Bas"><region name="Gueldre"><name sortKey="Fransen, Jaap" sort="Fransen, Jaap" uniqKey="Fransen J" first="Jaap" last="Fransen">Jaap Fransen</name>
</region>
<name sortKey="Van Den Hoogen, Frank" sort="Van Den Hoogen, Frank" uniqKey="Van Den Hoogen F" first="Frank" last="Van Den Hoogen">Frank Van Den Hoogen</name>
<name sortKey="Vonk, Madelon C" sort="Vonk, Madelon C" uniqKey="Vonk M" first="Madelon C." last="Vonk">Madelon C. Vonk</name>
</country>
<country name="Suisse"><noRegion><name sortKey="Tyndall, Alan" sort="Tyndall, Alan" uniqKey="Tyndall A" first="Alan" last="Tyndall">Alan Tyndall</name>
</noRegion>
<name sortKey="Distler, Oliver" sort="Distler, Oliver" uniqKey="Distler O" first="Oliver" last="Distler">Oliver Distler</name>
<name sortKey="Walker, Ulrich A" sort="Walker, Ulrich A" uniqKey="Walker U" first="Ulrich A." last="Walker">Ulrich A. Walker</name>
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<name sortKey="Cappelli, Susanna" sort="Cappelli, Susanna" uniqKey="Cappelli S" first="Susanna" last="Cappelli">Susanna Cappelli</name>
<name sortKey="Gabrielli, Armando" sort="Gabrielli, Armando" uniqKey="Gabrielli A" first="Armando" last="Gabrielli">Armando Gabrielli</name>
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<country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Denton, Christopher P" sort="Denton, Christopher P" uniqKey="Denton C" first="Christopher P." last="Denton">Christopher P. Denton</name>
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<country name="États-Unis"><region name="Texas"><name sortKey="Mayes, Maureen" sort="Mayes, Maureen" uniqKey="Mayes M" first="Maureen" last="Mayes">Maureen Mayes</name>
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<name sortKey="Chung, Lorinda" sort="Chung, Lorinda" uniqKey="Chung L" first="Lorinda" last="Chung">Lorinda Chung</name>
<name sortKey="Clements, Phillip" sort="Clements, Phillip" uniqKey="Clements P" first="Phillip" last="Clements">Phillip Clements</name>
<name sortKey="Khanna, Dinesh" sort="Khanna, Dinesh" uniqKey="Khanna D" first="Dinesh" last="Khanna">Dinesh Khanna</name>
<name sortKey="Medsger, Thomas A" sort="Medsger, Thomas A" uniqKey="Medsger T" first="Thomas A." last="Medsger">Thomas A. Medsger</name>
<name sortKey="Merkel, Peter A" sort="Merkel, Peter A" uniqKey="Merkel P" first="Peter A." last="Merkel">Peter A. Merkel</name>
<name sortKey="Seibold, James R" sort="Seibold, James R" uniqKey="Seibold J" first="James R." last="Seibold">James R. Seibold</name>
<name sortKey="Silver, Richard" sort="Silver, Richard" uniqKey="Silver R" first="Richard" last="Silver">Richard Silver</name>
<name sortKey="Steen, Virginia" sort="Steen, Virginia" uniqKey="Steen V" first="Virginia" last="Steen">Virginia Steen</name>
<name sortKey="Varga, John" sort="Varga, John" uniqKey="Varga J" first="John" last="Varga">John Varga</name>
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<country name="Espagne"><region name="Communauté de Madrid"><name sortKey="Carreira, Patricia E" sort="Carreira, Patricia E" uniqKey="Carreira P" first="Patricia E." last="Carreira">Patricia E. Carreira</name>
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</record>

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{{Explor lien
   |wiki=    Wicri/Amérique
   |area=    PittsburghV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     PMC:4134523
   |texte=   Systemic Sclerosis Classification Criteria: Developing methods for multi-criteria decision analysis with 1000Minds
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Serveur d'exploration sur Pittsburgh

Systemic Sclerosis Classification Criteria: Developing methods for multi-criteria decision analysis with 1000Minds

Systemic Sclerosis Classification Criteria: Developing methods for multi-criteria decision analysis with 1000Minds

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Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

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